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The GABA receptor GABRR1 is expressed on and functional in hematopoietic stem cells and megakaryocyte progenitors

GABRR1 is a rho subunit receptor of GABA, the major inhibitory neurotransmitter in the mammalian brain. While most investigations of its function focused on the nervous system, its regulatory role in hematopoiesis has not been reported. In this study, we found GABRR1 is mainly expressed on subsets o...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Zhu, Fangfang, Feng, Mingye, Sinha, Rahul, Murphy, Matthew Philip, Luo, Fujun, Kao, Kevin S., Szade, Krzysztof, Seita, Jun, Weissman, Irving L.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2019
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744911/
https://ncbi.nlm.nih.gov/pubmed/31451629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906251116
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