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The GABA receptor GABRR1 is expressed on and functional in hematopoietic stem cells and megakaryocyte progenitors

GABRR1 is a rho subunit receptor of GABA, the major inhibitory neurotransmitter in the mammalian brain. While most investigations of its function focused on the nervous system, its regulatory role in hematopoiesis has not been reported. In this study, we found GABRR1 is mainly expressed on subsets o...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zhu, Fangfang, Feng, Mingye, Sinha, Rahul, Murphy, Matthew Philip, Luo, Fujun, Kao, Kevin S., Szade, Krzysztof, Seita, Jun, Weissman, Irving L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744911/
https://ncbi.nlm.nih.gov/pubmed/31451629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906251116
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