The GABA receptor GABRR1 is expressed on and functional in hematopoietic stem cells and megakaryocyte progenitors

GABRR1 is a rho subunit receptor of GABA, the major inhibitory neurotransmitter in the mammalian brain. While most investigations of its function focused on the nervous system, its regulatory role in hematopoiesis has not been reported. In this study, we found GABRR1 is mainly expressed on subsets o...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Zhu, Fangfang, Feng, Mingye, Sinha, Rahul, Murphy, Matthew Philip, Luo, Fujun, Kao, Kevin S., Szade, Krzysztof, Seita, Jun, Weissman, Irving L.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2019
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744911/
https://ncbi.nlm.nih.gov/pubmed/31451629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906251116
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