Pore-modulating toxins exploit inherent slow inactivation to block K(+) channels

Voltage-dependent potassium channels (K(v)s) gate in response to changes in electrical membrane potential by coupling a voltage-sensing module with a K(+)-selective pore. Animal toxins targeting K(v)s are classified as pore blockers, which physically plug the ion conduction pathway, or as gating mod...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Karbat, Izhar, Altman-Gueta, Hagit, Fine, Shachar, Szanto, Tibor, Hamer-Rogotner, Shelly, Dym, Orly, Frolow, Felix, Gordon, Dalia, Panyi, Gyorgy, Gurevitz, Michael, Reuveny, Eitan
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2019
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744907/
https://ncbi.nlm.nih.gov/pubmed/31444298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1908903116
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