Quantitative Insights into Age-Associated DNA-Repair Inefficiency in Single Cells

Although double-strand break (DSB) repair is essential for a cell’s survival, little is known about how DSB repair mechanisms are affected by age. Here we characterize the impact of cellular aging on the efficiency of single-strand annealing (SSA), a DSB repair mechanism. We measure SSA repair effic...

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Udgivet i:Cell Rep
Main Authors: Young, Thomas Z., Liu, Ping, Urbonaite, Guste, Acar, Murat
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744837/
https://ncbi.nlm.nih.gov/pubmed/31433994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.07.082
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