Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia

BACKGROUND: Preeclampsia is a pregnancy-specific hypertensive disorder characterized by impaired angiogenesis. We postulate that senescence of mesenchymal stem cells (MSC), multipotent cells with pro-angiogenic activities, is one of the mechanisms by which systemic inflammation exerts inhibitory eff...

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Detalhes bibliográficos
Publicado no:Biol Sex Differ
Main Authors: Suvakov, Sonja, Cubro, Hajrunisa, White, Wendy M., Butler Tobah, Yvonne S., Weissgerber, Tracey L., Jordan, Kyra L., Zhu, Xiang Y., Woollard, John R., Chebib, Fouad T., Milic, Natasa M., Grande, Joseph P., Xu, Ming, Tchkonia, Tamara, Kirkland, James L., Lerman, Lilach O., Garovic, Vesna D.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744626/
https://ncbi.nlm.nih.gov/pubmed/31521202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13293-019-0263-5
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