Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia

BACKGROUND: Preeclampsia is a pregnancy-specific hypertensive disorder characterized by impaired angiogenesis. We postulate that senescence of mesenchymal stem cells (MSC), multipotent cells with pro-angiogenic activities, is one of the mechanisms by which systemic inflammation exerts inhibitory eff...

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Veröffentlicht in:Biol Sex Differ
Hauptverfasser: Suvakov, Sonja, Cubro, Hajrunisa, White, Wendy M., Butler Tobah, Yvonne S., Weissgerber, Tracey L., Jordan, Kyra L., Zhu, Xiang Y., Woollard, John R., Chebib, Fouad T., Milic, Natasa M., Grande, Joseph P., Xu, Ming, Tchkonia, Tamara, Kirkland, James L., Lerman, Lilach O., Garovic, Vesna D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744626/
https://ncbi.nlm.nih.gov/pubmed/31521202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13293-019-0263-5
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