Assessment of methods for predicting the effects of PTEN and TPMT protein variants

Thermodynamic stability is a fundamental property shared by all proteins. Changes in stability due to mutation are a widespread molecular mechanism in genetic diseases. Methods for the prediction of mutation-induced stability change have typically been developed and evaluated on incomplete and/or bi...

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Veröffentlicht in:Hum Mutat
Hauptverfasser: Pejaver, Vikas, Babbi, Giulia, Casadio, Rita, Folkman, Lukas, Katsonis, Panagiotis, Kundu, Kunal, Lichtarge, Olivier, Martelli, Pier Luigi, Miller, Maximillian, Moult, John, Pal, Lipika R., Savojardo, Castrense, Yin, Yizhou, Zhou, Yaoqi, Radivojac, Predrag, Bromberg, Yana
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744362/
https://ncbi.nlm.nih.gov/pubmed/31184403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.23838
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