HCF-1 regulates de novo lipogenesis through a nutrient sensitive complex with ChREBP

Carbohydrate response element binding protein (ChREBP) is a key transcriptional regulator of de novo lipogenesis (DNL) in response to carbohydrates and in hepatic steatosis. As such, mechanisms underlying nutrient modulation of ChREBP are under active investigation. Here, we identify Host Cell Facto...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Lane, Elizabeth A., Choi, Dong Wook, Garcia-Haro, Luisa, Levine, Zebulon G., Tedoldi, Meghan, Walker, Suzanne, Danial, Nika N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744259/
https://ncbi.nlm.nih.gov/pubmed/31227231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.05.019
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