SNX8 Enhances Non-amyloidogenic APP Trafficking and Attenuates Aβ Accumulation and Memory Deficits in an AD Mouse

Dysregulation of various APP trafficking components in the endosome has been previously implicated in Alzheimer’s disease (AD). Although single nucleotide polymorphisms within the gene locus encoding the endosomal component, SNX8 have been previously associated with AD, how SNX8 levels are altered a...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Xie, Yongzhuang, Niu, Mengxi, Ji, Chengxiang, Huang, Timothy Y., Zhang, Cuilin, Tian, Ye, Shi, Zhun, Wang, Chen, Zhao, Yingjun, Luo, Hong, Can, Dan, Xu, Huaxi, Zhang, Yun-wu, Zhang, Xian
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6743354/
https://ncbi.nlm.nih.gov/pubmed/31551717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00410
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