Parallel Accumulation of Tumor Hyaluronan, Collagen, and Other Drivers of Tumor Progression

PURPOSE: The tumor microenvironment (TME) evolves to support tumor progression. One marker of more aggressive malignancy is hyaluronan (HA) accumulation. Here, we characterize biological and physical changes associated with HA-accumulating (HA-high) tumors. EXPERIMENTAL DESIGN: We used immunohistoch...

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Publié dans:Clin Cancer Res
Auteurs principaux: Li, Xiaoming, Shepard, Michael H., Cowell, Jessica A., Zhao, Chunmei, Osgood, Ryan J., Rosengren, Sanna, Blouw, Barbara, Garrovillo, Sheryl A., Pagel, Mark D., Whatcott, Clifford J., Han, Haiyong, Von Hoff, Daniel D., Taverna, Darin M., LaBarre, Michael J., Maneval, Daniel C., Thompson, Curtis B.
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6743334/
https://ncbi.nlm.nih.gov/pubmed/30084839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-3284
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