The growth of a xenograft breast cancer tumor model with engineered hyaluronan-accumulating stroma is dependent on hyaluronan and independent of CD44

Hyaluronan accumulation in the tumor microenvironment is associated with poor prognosis in several solid human cancers. To understand the role of stromal hyaluronan in tumor progression, we engineered 3T3HAS3, a hyaluronan-producing fibroblast cell line, by lentiviral transduction of Balb/c 3T3 cell...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Zhao, Chunmei, Thompson, Benjamin J., Chen, Kelly, Gao, Feng, Blouw, Barbara, Marella, Mathieu, Zimmerman, Susan, Kimbler, Trevor, Garrovillo, Sheryl, Bahn, Jesse, Huang, Lei, Huang, Zhongdong, Shepard, H. Michael, Rosengren, Sanna, Thanos, Christopher D., Maneval, Daniel C.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2019
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6859925/
https://ncbi.nlm.nih.gov/pubmed/31762938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27302
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