Improved GaLV-TR Glycoproteins to Pseudotype Lentiviral Vectors: Impact of Viral Protease Activity in the Production of LV Pseudotypes

Lentiviral vectors (LVs) are excellent tools for gene transfer into mammalian cells. It is noteworthy that the first gene therapy treatment using LVs was approved for commercialization in 2017. The G glycoprotein from rhabdovirus vesicular stomatitis virus (VSV-G) is the glycoprotein most used to ps...

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Bibliographic Details
Published in:Mol Ther Methods Clin Dev
Main Authors: Tomás, Hélio A., Mestre, Daniel A., Rodrigues, Ana F., Guerreiro, Miguel R., Carrondo, Manuel J.T., Coroadinha, Ana Sofia
Format: Artigo
Language:Inglês
Published: American Society of Gene & Cell Therapy 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6742969/
https://ncbi.nlm.nih.gov/pubmed/31528654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2019.08.001
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