Cerebrospinal Fluid and Brain Tissue Penetration of Tenofovir, Lamivudine, and Efavirenz in Postmortem Tissues with Cryptococcal Meningitis

The central nervous system (CNS) is a known HIV reservoir, yet little is known about drug exposure in the brain. Our primary objective was to quantify exposure of three common antiretrovirals in brain tissue and compare exposures to plasma and cerebrospinal fluid (CSF). We also sought to identify po...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Clin Transl Sci
Prif Awduron: Nicol, Melanie R., Pastick, Katelyn A., Taylor, Joneé, Namuju, Olivie C., Rhein, Joshua, Williams, Darlisha A., Meya, David B., Boulware, David R., Lukande, Robert
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2019
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6742940/
https://ncbi.nlm.nih.gov/pubmed/31207069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12661
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