Cerebrospinal Fluid and Brain Tissue Penetration of Tenofovir, Lamivudine, and Efavirenz in Postmortem Tissues with Cryptococcal Meningitis

The central nervous system (CNS) is a known HIV reservoir, yet little is known about drug exposure in the brain. Our primary objective was to quantify exposure of three common antiretrovirals in brain tissue and compare exposures to plasma and cerebrospinal fluid (CSF). We also sought to identify po...

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Bibliografiske detaljer
Udgivet i:Clin Transl Sci
Main Authors: Nicol, Melanie R., Pastick, Katelyn A., Taylor, Joneé, Namuju, Olivie C., Rhein, Joshua, Williams, Darlisha A., Meya, David B., Boulware, David R., Lukande, Robert
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6742940/
https://ncbi.nlm.nih.gov/pubmed/31207069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12661
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