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Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations
Each human genome carries tens of thousands of coding variants. The extent to which this variation is functional and the mechanisms by which they exert their influence remains largely unexplored. To address this gap, we leverage the ExAC database of 60,706 human exomes to investigate experimentally...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6742646/ https://ncbi.nlm.nih.gov/pubmed/31515488 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11959-3 |
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