Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

Each human genome carries tens of thousands of coding variants. The extent to which this variation is functional and the mechanisms by which they exert their influence remains largely unexplored. To address this gap, we leverage the ExAC database of 60,706 human exomes to investigate experimentally...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Nat Commun
Main Authors: Fragoza, Robert, Das, Jishnu, Wierbowski, Shayne D., Liang, Jin, Tran, Tina N., Liang, Siqi, Beltran, Juan F., Rivera-Erick, Christen A., Ye, Kaixiong, Wang, Ting-Yi, Yao, Li, Mort, Matthew, Stenson, Peter D., Cooper, David N., Wei, Xiaomu, Keinan, Alon, Schimenti, John C., Clark, Andrew G., Yu, Haiyuan
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group UK 2019
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6742646/
https://ncbi.nlm.nih.gov/pubmed/31515488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11959-3
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