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Schedule-dependent potentiation of chemotherapy drugs by the hypoxia-activated prodrug SN30000
Hypoxia-activated prodrugs (HAPs) are hypothesized to improve the therapeutic index of chemotherapy drugs that are ineffective against tumor cells in hypoxic microenvironments. SN30000 (CEN-209) is a benzotriazine di-N-oxide HAP that potentiates radiotherapy in preclinical models, but its combinatio...
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| Udgivet i: | Cancer Biol Ther |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Taylor & Francis
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6741573/ https://ncbi.nlm.nih.gov/pubmed/31131698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2019.1617570 |
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