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An agent-based model for drug-radiation interactions in the tumour microenvironment: Hypoxia-activated prodrug SN30000 in multicellular tumour spheroids.

Multicellular tumour spheroids capture many characteristics of human tumour microenvironments, including hypoxia, and represent an experimentally tractable in vitro model for studying interactions between radiotherapy and anticancer drugs. However, interpreting spheroid data is challenging because o...

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主要な著者: Xinjian Mao, Sarah McManaway, Jagdish K Jaiswal, Priyanka B Patel, William R Wilson, Kevin O Hicks, Gib Bogle
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science (PLoS) 2018-10-01
シリーズ:PLoS Computational Biology
オンライン・アクセス:http://europepmc.org/articles/PMC6218095?pdf=render
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