Schedule-dependent potentiation of chemotherapy drugs by the hypoxia-activated prodrug SN30000

Hypoxia-activated prodrugs (HAPs) are hypothesized to improve the therapeutic index of chemotherapy drugs that are ineffective against tumor cells in hypoxic microenvironments. SN30000 (CEN-209) is a benzotriazine di-N-oxide HAP that potentiates radiotherapy in preclinical models, but its combinatio...

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Detaylı Bibliyografya
Yayımlandı:Cancer Biol Ther
Asıl Yazarlar: Mao, Xinjian, McManaway, Sarah, Jaiswal, Jagdish K., Hong, Cho R., Wilson, William R., Hicks, Kevin O.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Taylor & Francis 2019
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6741573/
https://ncbi.nlm.nih.gov/pubmed/31131698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2019.1617570
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