Expanded Analysis of Secondary Germline Findings From Matched Tumor/Normal Sequencing Identifies Additional Clinically Significant Mutations

PURPOSE: Next-generation sequencing (NGS) for tumor molecular profiling can reveal secondary germline likely pathogenic and pathogenic variants (LPV/PV). The American College of Medical Genetics and Genomics (ACMG) recommends return of secondary results for a subset of 59 genes, but other genes with...

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Detalhes bibliográficos
Publicado no:JCO Precis Oncol
Main Authors: Ileana Dumbrava, Ecaterina, Brusco, Lauren, Daniels, Molly S., Wathoo, Chetna, Shaw, Kenna R., Lu, Karen H., Zheng, Xiaofeng, Strong, Louise C., Litton, Jennifer, Arun, Banu K., Eterovic, A. Karina, Routbort, Mark J., Patel, Keyur P., Qi, Yuan, Piha-Paul, Sarina A., Subbiah, Vivek, Hong, David S., Rodon, Jordi, Kopetz, Scott, Mendelsohn, John, Mills, Gordon B., Chen, Ken, Meric-Bernstam, Funda
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2019
Assuntos:
Original Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6741435/
https://ncbi.nlm.nih.gov/pubmed/31517177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.18.00143
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