Targeting ERBB2 (HER2) Amplification Identified by Next-Generation Sequencing in Patients With Advanced or Metastatic Solid Tumors Beyond Conventional Indications

PURPOSE: Human epidermal growth factor receptor 2 (HER2) is an effective therapeutic target in breast and gastric and gastroesophageal junction cancers. However, less is known about the prevalence of ERBB2 (HER2) amplification and the efficacy of HER2-targeted treatment in other tumors. PATIENTS AND...

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Detalhes bibliográficos
Publicado no:JCO Precis Oncol
Main Authors: Dumbrava, Ecaterina E. Ileana, Balaji, Kavitha, Raghav, Kanwal, Hess, Kenneth, Javle, Milind, Blum-Murphy, Mariela, Ajani, Jaffer, Kopetz, Scott, Broaddus, Russell, Routbort, Mark, Demirhan, Mehmet, Zheng, Xiaofeng, Pant, Shubham, Tsimberidou, Apostolia M., Subbiah, Vivek, Hong, David S., Rodon, Jordi, Shaw, Kenna M., Piha-Paul, Sarina A., Meric-Bernstam, Funda
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2019
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446516/
https://ncbi.nlm.nih.gov/pubmed/32923865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.18.00345
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