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The Production of Amyloid β Peptide Is a Critical Requirement for the Viability of Central Neurons

The amyloid β peptide (Aβ) is a product of the sequential γ- and β-secretase cleavage of amyloid precursor protein. Inhibitors of secretase enzymes have been proposed as a potential therapeutic strategy in the treatment of Alzheimer's disease. Here, we investigate the effect of inhibiting these...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Plant, Leigh D., Boyle, John P., Smith, Ian F., Peers, Chris, Pearson, Hugh A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6741264/
https://ncbi.nlm.nih.gov/pubmed/12843253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-13-05531.2003
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