A Conditional Deletion of the NR1 Subunit of the NMDA Receptor in Adult Spinal Cord Dorsal Horn Reduces NMDA Currents and Injury-Induced Pain

To determine the importance of the NMDA receptor (NMDAR) in pain hypersensitivity after injury, the NMDAR1 (NR1) subunit was selectively deleted in the lumbar spinal cord of adult mice by the localized injection of an adenoassociated virus expressing Cre recombinase into floxed NR1 mice. NR1 subunit...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: South, Samantha M., Kohno, Tatsuro, Kaspar, Brian K., Hegarty, Deborah, Vissel, Bryce, Drake, Carrie T., Ohata, Megumi, Jenab, Shirzad, Sailer, Andreas W., Malkmus, Shelle, Masuyama, Takashi, Horner, Philip, Bogulavsky, Johanna, Gage, Fred H., Yaksh, Tony L., Woolf, Clifford J., Heinemann, Stephen F., Inturrisi, Charles E.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2003
Assuntos:
Cellular/Molecular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6741202/
https://ncbi.nlm.nih.gov/pubmed/12832526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-12-05031.2003
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