A Conditional Deletion of the NR1 Subunit of the NMDA Receptor in Adult Spinal Cord Dorsal Horn Reduces NMDA Currents and Injury-Induced Pain

To determine the importance of the NMDA receptor (NMDAR) in pain hypersensitivity after injury, the NMDAR1 (NR1) subunit was selectively deleted in the lumbar spinal cord of adult mice by the localized injection of an adenoassociated virus expressing Cre recombinase into floxed NR1 mice. NR1 subunit...

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Publicado en:J Neurosci
Autores principales: South, Samantha M., Kohno, Tatsuro, Kaspar, Brian K., Hegarty, Deborah, Vissel, Bryce, Drake, Carrie T., Ohata, Megumi, Jenab, Shirzad, Sailer, Andreas W., Malkmus, Shelle, Masuyama, Takashi, Horner, Philip, Bogulavsky, Johanna, Gage, Fred H., Yaksh, Tony L., Woolf, Clifford J., Heinemann, Stephen F., Inturrisi, Charles E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2003
Materias:
Cellular/Molecular
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6741202/
https://ncbi.nlm.nih.gov/pubmed/12832526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-12-05031.2003
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