Long-Term K(+) Channel-Mediated Dampening of Dopamine Neuron Excitability by the Antipsychotic Drug Haloperidol

Antipsychotic drugs require days of treatment to begin to produce therapeutic effects. We report that in vivo treatment with the antipsychotic drug haloperidol acts with a delay of days to slow spontaneous repetitive firing by isolated midbrain dopamine neurons. The decreased excitability is caused...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Hahn, Junghyun, Tse, Tonia E., Levitan, Edwin S.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2003
Subjects:
Cellular/Molecular
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740975/
https://ncbi.nlm.nih.gov/pubmed/14645479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-34-10859.2003
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