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Action potentials and amphetamine release antipsychotic drug from dopamine neuron synaptic VMAT vesicles

Based on lysotracker red imaging in cultured hippocampal neurons, antipsychotic drugs (APDs) were proposed to accumulate in synaptic vesicles by acidic trapping and to be released in response to action potentials. Because many APDs are dopamine (DA) D2 receptor (D2R) antagonists, such a mechanism wo...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Tucker, Kristal R., Block, Ethan R., Levitan, Edwin S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538645/
https://ncbi.nlm.nih.gov/pubmed/26216995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503766112
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