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Action potentials and amphetamine release antipsychotic drug from dopamine neuron synaptic VMAT vesicles
Based on lysotracker red imaging in cultured hippocampal neurons, antipsychotic drugs (APDs) were proposed to accumulate in synaptic vesicles by acidic trapping and to be released in response to action potentials. Because many APDs are dopamine (DA) D2 receptor (D2R) antagonists, such a mechanism wo...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4538645/ https://ncbi.nlm.nih.gov/pubmed/26216995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503766112 |
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