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Mathematical analysis of depolarization block mediated by slow inactivation of fast sodium channels in midbrain dopamine neurons
Dopamine neurons in freely moving rats often fire behaviorally relevant high-frequency bursts, but depolarization block limits the maximum steady firing rate of dopamine neurons in vitro to ∼10 Hz. Using a reduced model that faithfully reproduces the sodium current measured in these neurons, we show...
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| Publicado no: | J Neurophysiol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4254877/ https://ncbi.nlm.nih.gov/pubmed/25185810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00578.2014 |
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