Hypoglycemic Neuronal Death and Cognitive Impairment Are Prevented by Poly(ADP-Ribose) Polymerase Inhibitors Administered after Hypoglycemia

Severe hypoglycemia causes neuronal death and cognitive impairment. Evidence suggests that hypoglycemic neuronal death involves excitotoxicity and DNA damage. Poly(ADP-ribose) polymerase-1 (PARP-1) normally functions in DNA repair, but promotes cell death when extensively activated by DNA damage. Co...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Suh, Sang Won, Aoyama, Koji, Chen, Yongmei, Garnier, Philippe, Matsumori, Yasuhiko, Gum, Elizabeth, Liu, Jialing, Swanson, Raymond A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2003
Assuntos:
Cellular/Molecular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740913/
https://ncbi.nlm.nih.gov/pubmed/14627653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-33-10681.2003
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