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Insulin-Like Growth Factor (IGF) Signaling through Type 1 IGF Receptor Plays an Important Role in Remyelination

We examined the role of IGF signaling in the remyelination process by disrupting the gene encoding the type 1 IGF receptor (IGF1R) specifically in the mouse brain by Cre-mediated recombination and then exposing these mutants and normal siblings to cuprizone. This neurotoxicant induces a demyelinatin...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Mason, Jeffrey L., Xuan, Shouhong, Dragatsis, Ioannis, Efstratiadis, Argiris, Goldman, James E.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740767/
https://ncbi.nlm.nih.gov/pubmed/12930811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-20-07710.2003
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