Insulin-Like Growth Factor (IGF) Signaling through Type 1 IGF Receptor Plays an Important Role in Remyelination

We examined the role of IGF signaling in the remyelination process by disrupting the gene encoding the type 1 IGF receptor (IGF1R) specifically in the mouse brain by Cre-mediated recombination and then exposing these mutants and normal siblings to cuprizone. This neurotoxicant induces a demyelinatin...

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Vydáno v:J Neurosci
Hlavní autoři: Mason, Jeffrey L., Xuan, Shouhong, Dragatsis, Ioannis, Efstratiadis, Argiris, Goldman, James E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2003
Témata:
Development/Plasticity/Repair
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740767/
https://ncbi.nlm.nih.gov/pubmed/12930811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-20-07710.2003
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