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APOE polymorphism and clinical duration determine regional neuropathology in Swedish APP(670, 671) mutation carriers: implications for late‐onset Alzheimer's disease
Neurofibrillary changes throughout the brain were investigated for three relatives who carried the Swedish APP(670,671) mutation which causes overproduction of Aβ40 and Aβ42. They differed in terms of APOE genotype, age at the onset of dementia, and disease duration (P1: ɛ2/3, age 57, 11 years; P2:...
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| Veröffentlicht in: | J Cell Mol Med |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Blackwell Publishing Ltd
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6740279/ https://ncbi.nlm.nih.gov/pubmed/12169205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2002.tb00187.x |
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