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Instability in a coiled‐coil signaling helix is conserved for signal transduction in soluble guanylyl cyclase
How nitric oxide (NO) activates its primary receptor, α1/β1 soluble guanylyl cyclase (sGC or GC‐1), remains unknown. Likewise, how stimulatory compounds enhance sGC activity is poorly understood, hampering development of new treatments for cardiovascular disease. NO binding to ferrous heme near the...
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| Publicado no: | Protein Sci |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley & Sons, Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6739824/ https://ncbi.nlm.nih.gov/pubmed/31411784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3707 |
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