Discovery of stimulator binding to a conserved pocket in the heme domain of soluble guanylyl cyclase

Soluble guanylyl cyclase (sGC) is the receptor for nitric oxide and a highly sought-after therapeutic target for the management of cardiovascular diseases. New compounds that stimulate sGC show clinical promise, but where these stimulator compounds bind and how they function remains unknown. Here, u...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Wales, Jessica A., Chen, Cheng-Yu, Breci, Linda, Weichsel, Andrzej, Bernier, Sylvie G., Sheppeck, James E., Solinga, Robert, Nakai, Takashi, Renhowe, Paul A., Jung, Joon, Montfort, William R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798312/
https://ncbi.nlm.nih.gov/pubmed/29222330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000457
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