Amino Acid Substitutions in Genotype 3a Hepatitis C Virus Polymerase Protein Affect Responses to Sofosbuvir

BACKGROUND & AIMS: Sofosbuvir is a frequently used pan-genotype inhibitor of hepatitis C virus (HCV) polymerase. This drug eliminates most chronic HCV infections, and resistance-associated substitutions in the polymerase are rare. However, HCV genotype 3 responds slightly less well to sofosbuvir...

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Udgivet i:Gastroenterology
Main Authors: Wing, Peter A.C., Jones, Meleri, Cheung, Michelle, DaSilva, Sampath, Bamford, Connor, Jason Lee, Wing-Yiu, Aranday-Cortes, Elihu, Da Silva Filipe, Ana, McLauchlan, John, Smith, David, Irving, William, Cunningham, Morven, Ansari, Azim, Barnes, Eleanor, Foster, Graham R.
Format: Artigo
Sprog:Inglês
Udgivet: W.B. Saunders 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6739484/
https://ncbi.nlm.nih.gov/pubmed/31078622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2019.05.007
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