Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes

Pediatric malignancies including Ewing sarcoma (EwS) feature a paucity of somatic alterations except for pathognomonic driver-mutations that cannot explain overt variations in clinical outcome. Here, we demonstrate in EwS how cooperation of dominant oncogenes and regulatory germline variants determi...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Musa, Julian, Cidre-Aranaz, Florencia, Aynaud, Marie-Ming, Orth, Martin F., Knott, Maximilian M. L., Mirabeau, Olivier, Mazor, Gal, Varon, Mor, Hölting, Tilman L. B., Grossetête, Sandrine, Gartlgruber, Moritz, Surdez, Didier, Gerke, Julia S., Ohmura, Shunya, Marchetto, Aruna, Dallmayer, Marlene, Baldauf, Michaela C., Stein, Stefanie, Sannino, Giuseppina, Li, Jing, Romero-Pérez, Laura, Westermann, Frank, Hartmann, Wolfgang, Dirksen, Uta, Gymrek, Melissa, Anderson, Nathaniel D., Shlien, Adam, Rotblat, Barak, Kirchner, Thomas, Delattre, Olivier, Grünewald, Thomas G. P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6739408/
https://ncbi.nlm.nih.gov/pubmed/31511524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12071-2
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