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Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination
TIR domain-containing adaptor inducing interferon-β (TRIF) is an essential adaptor protein required for innate immune responses mediated by Toll-like receptor (TLR) 3- and TLR4. Here we identify USP19 as a negative regulator of TLR3/4-mediated signaling. USP19 deficiency increases the production of...
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| Опубликовано в: : | Nat Commun |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6739404/ https://ncbi.nlm.nih.gov/pubmed/31511519 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12145-1 |
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