TRIM21 Promotes Innate Immune Response to RNA Viral Infection through Lys27-Linked Polyubiquitination of MAVS

Human innate immunity responds to viral infection by activating the production of interferons (IFNs) and proinflammatory cytokines. The mitochondrial adaptor molecule MAVS plays a critical role in innate immune response to viral infection. In this study, we show that TRIM21 (tripartite motif-contain...

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發表在:J Virol
Main Authors: Xue, Binbin, Li, Huiyi, Guo, Mengmeng, Wang, Jingjing, Xu, Yan, Zou, Xuan, Deng, Rilin, Li, Guangdi, Zhu, Haizhen
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2018
主題:
Pathogenesis and Immunity
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026736/
https://ncbi.nlm.nih.gov/pubmed/29743353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00321-18
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