Decreased Obg-like ATPase-1 (OLA1) Expression Drives Ubiquitin-Proteasome Pathways to Downregulate Mitochondrial Superoxide Dismutase (SOD2) in Persistent Pulmonary Hypertension of the Newborn

Persistent pulmonary hypertension of the newborn (PPHN) is a failure of pulmonary vascular resistance to decline at birth rapidly. One principal mechanism implicated in PPHN development is mitochondrial oxidative stress. Expression and activity of mitochondrial superoxide dismutase (SOD2) are decrea...

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Vydáno v:Hypertension
Hlavní autoři: Schultz, Adam, Olorundami, Olubunmi A., Teng, Ru-Jeng, Jarzembowski, Jason, Shi, Zheng-Zheng, Kumar, Suresh N, Pritchard, Kirkwood, Konduri, Girija G., Afolayan, Adeleye J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6739165/
https://ncbi.nlm.nih.gov/pubmed/31476900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.119.13430
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