Inducible HSP70 regulates superoxide dismutase-2 and mitochondrial oxidative stress in the endothelial cells from developing lungs

Superoxide dismutase 2 (SOD-2) is synthesized in the cytosol and imported into the mitochondrial matrix, where it is activated and functions as the primary antioxidant for cellular respiration. The specific mechanisms that target SOD-2 to the mitochondria remain unclear. We hypothesize that inducibl...

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Detalhes bibliográficos
Main Authors: Afolayan, Adeleye J., Teng, Ru-Jeng, Eis, Annie, Rana, Ujala, Broniowska, Katarzyna A., Corbett, John A., Pritchard, Kirkwood, Konduri, Girija G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920226/
https://ncbi.nlm.nih.gov/pubmed/24375796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00264.2013
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