Domain Mapping of Heat Shock Protein 70 Reveals That Glutamic Acid 446 and Arginine 447 Are Critical for Regulating Superoxide Dismutase 2 Function

Stress-inducible heat shock protein 70 (hsp70) interacts with superoxide dismutase 2 (SOD2) in the cytosol after synthesis to transfer the enzyme to the mitochondria for subsequent activation. However, the structural basis for this interaction remains to be defined. To map the SOD2-binding site in h...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Afolayan, Adeleye J., Alexander, Maxwell, Holme, Rebecca L., Michalkiewicz, Teresa, Rana, Ujala, Teng, Ru-Jeng, Zemanovic, Sara, Sahoo, Daisy, Pritchard, Kirkwood A., Konduri, Girija G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5313107/
https://ncbi.nlm.nih.gov/pubmed/28028182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.756122
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