VPS13D Gene Variant Is Associated with Altered IL-6 Production and Mortality in Septic Shock

BACKGROUND: Genetic variations contribute to septic shock mortality. To discover a novel locus, we performed in vitro genome-wide association studies (GWAS) and further tested the result in a cohort of septic shock patients. METHODS: Two in vitro GWAS using a quantitative trait locus analysis of sti...

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Bibliografische gegevens
Gepubliceerd in:J Innate Immun
Hoofdauteurs: Nakada, Taka-aki, Boyd, John H., Russell, James A., Aguirre-Hernández, Rosalía, Wilkinson, Mark D., Thair, Simone A., Nakada, Emiri, McConechy, Melissa K., Fjell, Christopher D., Walley, Keith R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: S. Karger AG 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6738836/
https://ncbi.nlm.nih.gov/pubmed/25896417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000381265
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