LAV-BPIFB4 associates with reduced frailty in humans and its transfer prevents frailty progression in old mice

Background: There is an increasing concern about age-related frailty because of the growing number of elderly people in the general population. The Longevity-Associated Variant (LAV) of the human BPIFB4 gene was found to correct endothelial dysfunction, one of the mechanisms underlying frailty, in a...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Malavolta, Marco, Dato, Serena, Villa, Francesco, Rango, Francesco De, Iannone, Francesca, Ferrario, Anna, Maciag, Anna, Ciaglia, Elena, D'amato, Antonio, Carrizzo, Albino, Basso, Andrea, Orlando, Fiorenza, Provinciali, Mauro, Madeddu, Paolo, Passarino, Giuseppe, Vecchione, Carmine, Rose, Giuseppina, Puca, Annibale A.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6738439/
https://ncbi.nlm.nih.gov/pubmed/31461407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102209
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