LAV-BPIFB4 associates with reduced frailty in humans and its transfer prevents frailty progression in old mice

Background: There is an increasing concern about age-related frailty because of the growing number of elderly people in the general population. The Longevity-Associated Variant (LAV) of the human BPIFB4 gene was found to correct endothelial dysfunction, one of the mechanisms underlying frailty, in a...

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Dades bibliogràfiques
Publicat a:Aging (Albany NY)
Autors principals: Malavolta, Marco, Dato, Serena, Villa, Francesco, Rango, Francesco De, Iannone, Francesca, Ferrario, Anna, Maciag, Anna, Ciaglia, Elena, D'amato, Antonio, Carrizzo, Albino, Basso, Andrea, Orlando, Fiorenza, Provinciali, Mauro, Madeddu, Paolo, Passarino, Giuseppe, Vecchione, Carmine, Rose, Giuseppina, Puca, Annibale A.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals 2019
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6738439/
https://ncbi.nlm.nih.gov/pubmed/31461407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102209
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