Vascular regression precedes motor neuron loss in the FUS (1-359) ALS mouse model

Amyotrophic lateral sclerosis (ALS) presents a poorly understood pathogenesis. Evidence from patients and mutant SOD1 mouse models suggests vascular damage may precede or aggravate motor dysfunction in ALS. We have previously shown angiogenin (ANG) treatment enhances motor neuron survival, delays mo...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Dis Model Mech
Prif Awduron: Crivello, Martin, Hogg, Marion C., Jirström, Elisabeth, Halang, Luise, Woods, Ina, Rayner, Megan, Coughlan, Karen S., Lewandowski, Sebastian A., Prehn, Jochen H. M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Company of Biologists Ltd 2019
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737946/
https://ncbi.nlm.nih.gov/pubmed/31383794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.040238
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