A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK

Activating mutations in GNAQ/GNA11, encoding Gαq G-proteins, are the cancer initiating oncogenes in uveal melanoma (UM). However, there are no effective therapies for UM. Using an integrated bioinformatics pipeline, we found that PTK2, encoding Focal Adhesion Kinase (FAK), represents a candidate syn...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Feng, Xiaodong, Arang, Nadia, Cosimo Rigiracciolo, Damiano, Sang Lee, Joo, Yeerna, Huwate, Wang, Zhiyong, Lubrano, Simone, Kishore, Ayush, Pachter, Jonathan A., Maggiolini, Marcello, Kostenis, Evi, Schlaepfer, David D., Tamayo, Pablo, Chen, Qianming, Ruppin, Eytan, Gutkind, J. Silvio
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737937/
https://ncbi.nlm.nih.gov/pubmed/30773340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.01.009
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