A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK

Activating mutations in GNAQ/GNA11, encoding Gαq G-proteins, are the cancer initiating oncogenes in uveal melanoma (UM). However, there are no effective therapies for UM. Using an integrated bioinformatics pipeline, we found that PTK2, encoding Focal Adhesion Kinase (FAK), represents a candidate syn...

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Bibliografiset tiedot
Julkaisussa:Cancer Cell
Päätekijät: Feng, Xiaodong, Arang, Nadia, Cosimo Rigiracciolo, Damiano, Sang Lee, Joo, Yeerna, Huwate, Wang, Zhiyong, Lubrano, Simone, Kishore, Ayush, Pachter, Jonathan A., Maggiolini, Marcello, Kostenis, Evi, Schlaepfer, David D., Tamayo, Pablo, Chen, Qianming, Ruppin, Eytan, Gutkind, J. Silvio
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737937/
https://ncbi.nlm.nih.gov/pubmed/30773340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.01.009
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