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Docking simulation and antibiotic discovery targeting the MlaC protein in Gram-negative bacteria

To maintain the lipid asymmetry of the cell envelope in Gram-negative bacteria, the MlaC protein serves as a lipid-transfer factor and delivers phospholipids from the outer to the inner membrane. A strategy of antibiotic discovery is to design a proper compound that can tightly bind to the MlaC prot...

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Detalhes bibliográficos
Publicado no:Chem Biol Drug Des
Main Authors: Huang, Yu-ming M., Munguia, Jason, Miao, Yinglong, Nizet, Victor, McCammon, J. Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737922/
https://ncbi.nlm.nih.gov/pubmed/30570806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.13462
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