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Cartilage endoplasmic reticulum stress may influence the onset but not the progression of experimental osteoarthritis

BACKGROUND: Osteoarthritis has been associated with a plethora of pathological factors and one which has recently emerged is chondrocyte endoplasmic reticulum (ER) stress. ER stress is sensed by key ER-resident stress sensors, one of which is activating transcription factor 6 (ATF6). The purpose of...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Kung, Louise H. W., Mullan, Lorna, Soul, Jamie, Wang, Ping, Mori, Kazutoshi, Bateman, John F., Briggs, Michael D., Boot-Handford, Raymond P.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737683/
https://ncbi.nlm.nih.gov/pubmed/31511053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-019-1988-6
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