Increased Classical Endoplasmic Reticulum Stress Is Sufficient to Reduce Chondrocyte Proliferation Rate in the Growth Plate and Decrease Bone Growth

Mutations in genes encoding cartilage oligomeric matrix protein and matrilin-3 cause a spectrum of chondrodysplasias called multiple epiphyseal dysplasia (MED) and pseudoachondroplasia (PSACH). The majority of these diseases feature classical endoplasmic reticulum (ER) stress and activation of the u...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kung, Louise H. W., Rajpar, M. Helen, Preziosi, Richard, Briggs, Michael D., Boot-Handford, Raymond P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334961/
https://ncbi.nlm.nih.gov/pubmed/25693198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117016
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