Targeted Induction of Endoplasmic Reticulum Stress Induces Cartilage Pathology

Pathologies caused by mutations in extracellular matrix proteins are generally considered to result from the synthesis of extracellular matrices that are defective. Mutations in type X collagen cause metaphyseal chondrodysplasia type Schmid (MCDS), a disorder characterised by dwarfism and an expande...

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Hauptverfasser: Rajpar, M. Helen, McDermott, Ben, Kung, Louise, Eardley, Rachel, Knowles, Lynette, Heeran, Mel, Thornton, David J., Wilson, Richard, Bateman, John F., Poulsom, Richard, Arvan, Peter, Kadler, Karl E., Briggs, Michael D., Boot-Handford, Raymond P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2009
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757901/
https://ncbi.nlm.nih.gov/pubmed/19834559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000691
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