Transgenic overexpression of active HDAC4 in the heart attenuates cardiac function and exacerbates remodeling in infarcted myocardium

Histone deacetylases (HDACs) play a critical role in modulating cardiac function and ischemic injury. HDAC4 was found to be elevated and activated in response to injury. However, whether HDAC4 mediates cardiac function is currently unknown. In this study, we created myocyte-specific activated HDAC4...

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Publicado en:J Appl Physiol (1985)
Autores principales: Zhang, Ling X., Du, Jianfeng, Zhao, Yu Tina, Wang, Jianguo, Zhang, Shouyan, Dubielecka, Patrycja M., Wei, Lei, Zhuang, Shougang, Qin, Gangjian, Chin, Y. Eugene, Zhao, Ting C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2018
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737459/
https://ncbi.nlm.nih.gov/pubmed/30284520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00006.2018
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